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KMID : 1130320160590060256
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Korean Journal of Pediatrics
2016 Volume.59 No. 6 p.256 ~ p.261
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Usefulness of interferon-γ release assay for the diagnosis of latent tuberculosis infection in young children
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Yun Ki-Wook
Kim Young-Kwang
Kim Hae-Ryun
Lee Mi-Kyung
Lim In-Seok
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Abstract
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Purpose: Latent tuberculosis infection (LTBI) in young children may progress to severe active tuberculosis (TB) disease and serve as a reservoir for future transmission of TB disease. There are limited data on interferon-γ release assay (IGRA) performance in young children, which our research aims to address by investigating the usefulness of IGRA for the diagnosis of LTBI.
Methods: We performed a tuberculin skin test (TST) and IGRA on children who were younger than 18 years and were admitted to Chung-Ang University Hospital during May 2011?June 2015. Blood samples for IGRA were collected, processed, and interpreted according to manufacturer protocol.
Results: Among 149 children, 31 (20.8%) and 10 (6.7%) were diagnosed with LTBI and active pulmonary TB, respectively. In subjects lacking contact history with active TB patients, TST and IGRA results were positive in 41.4% (29 of 70) and 12.9% (9 of 70) subjects, respectively. The agreement (kappa) of TST and IGRA was 0.123. The control group, consisting of non-TB-infected subjects, showed no correlation between age and changes in interferon-γ concentration after nil antigen, TB-specific antigen, or mitogen stimulation in IGRAs (P=0.384, P=0.176, and P=0.077, respectively). In serial IGRAs, interferon-γ response to TB antigen increased in IGRA-positive LTBI subjects, but did not change considerably in initially IGRA-negative LTBI or control subjects.
Conclusion: The lack of decrease in interferon-γ response in young children indicates that IGRA could be considered for this age group. Serial IGRA tests might accurately diagnose LTBI in children lacking contact history with active TB patients.
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KEYWORD
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Interferon-gamma release assay , Tuberculin skin test , Latent tuberculosis infection , Child
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